SLU-PP-332 / SLU-SENSIA — solución de 18 mg en 18 ml de DMSO (1 mg/ml), pureza ≥98%, para laboratorio e investigación
    SLU-PP-332 / SLU-SENSIA – fórmula estructural C18H14N2O2
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SLU-PP-332 / SLU-SENSIA — solución de 18 mg en 18 ml de DMSO (1 mg/ml), pureza ≥98%, para laboratorio e investigación
SLU-PP-332 / SLU-SENSIA – fórmula estructural C18H14N2O2

SLU-PP-332 (SLU-SENSIA) — research solution 18 mg/18 ml in DMSO (1 mg/ml), ≥98%

226,79 PLN
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SLU-PP-332

WARNING: Chemical reagent intended solely for laboratory, research and analytical purposes. NOT FOR HUMAN OR ANIMAL CONSUMPTION. It is not a medicinal product, dietary supplement or food.

SLU-PP-332 is a research compound described in the scientific literature as an agonist of the ERR receptors (estrogen-related receptors). The ERR receptors (ERRα, ERRβ, ERRγ) belong to the orphan nuclear receptor superfamily and are the subject of intensive research into energy metabolism, mitochondrial biogenesis and skeletal-muscle function. SLU-PP-332 appears in peer-reviewed literature as a pharmacological tool compound used to probe the activity of this receptor family in experimental models.

The material is supplied as a ready-made solution in DMSO, not as a powder: 18 mg of SLU-PP-332 dissolved in 18 ml of dimethyl sulfoxide, i.e. a concentration of 1.0 mg/ml (approx. 3.44 mmol/l). The chemical identity of the reagent has been confirmed against PubChem record CID 5338394 (CAS number 303760-60-3); the parameters in the table below are taken from that record. The purity of the base substance declared by the manufacturer is ≥ 98%; instrumental assay results for a specific shipment are stated in the Certificate of Analysis.

Physicochemical data

Systematic name (IUPAC)4-hydroxy-N-[(E)-naphthalen-2-ylmethylideneamino]benzamide
Equivalent name(E)-4-hydroxy-N′-(naphthalen-2-ylmethylene)benzohydrazide
Trade nameSLU-SENSIA (NONSENSIA brand) — the same compound, CAS 303760-60-3
SynonymsSLU-PP-332; PP-332; ERR agonist (pan-ERR)
CAS number303760-60-3
Molecular formulaC18H14N2O2
Molar mass290.3 g·mol−1 (monoisotopic mass 290.1055 Da)
Structural classaroylhydrazone (benzoic acid hydrazone) — a small molecule, not a peptide
Isomerismno stereogenic centre; the only isomerism is the C=N bond geometry — the material supplied is the (E) isomer
InChIKeyRNZIMBFHRXYRLL-XDHOZWIPSA-N
SMILES (isomeric)C1=CC=C2C=C(C=CC2=C1)/C=N/NC(=O)C3=CC=C(C=C3)O
Database identifiersPubChem CID 5338394 · ChEMBL CHEMBL4208749
Computed properties (PubChem)XLogP 3.7 · TPSA 61.7 Å2 · H-bond donors/acceptors 2/3 · rotatable bonds 3
Form suppliedclear to slightly yellow liquid solution (not a powder)
Package contents18 mg SLU-PP-332 in 18 ml DMSO — mass concentration 1.0 mg/ml, molar concentration approx. 3.44 mmol/l (3.44 mM)
Solventdimethyl sulfoxide (DMSO), analytical grade, ≥ 99.9%
Packagingglass vial with a screw cap, wrapped in light-protective film; packed in Poland
Purity of the base substance≥ 98% (manufacturer declaration)
Storagecool, dry, protected from light, in the originally closed bottle; DMSO is hygroscopic — limit exposure to moisture and avoid repeated freeze-thaw cycles

Characteristics and research application

SLU-PP-332 is used in basic research as an agonist of the ERR receptors — a class of nuclear receptors that regulate the expression of genes involved in oxidative metabolism, mitochondrial function and cellular energy balance. In the scientific literature this compound is indicated as a research tool for analysing ERR-dependent signalling pathways in in vitro and preclinical in vivo models, conducted exclusively under laboratory conditions.

The product is offered as a compound for advanced laboratory research, intended for reference work, validation of analytical methods and experiments carried out by qualified personnel. Because it is a relatively new research reagent with a limited set of widely available, confirmed physicochemical data, independent verification of the identity and purity of the material by instrumental methods (NMR, LC-MS, HPLC) on the basis of the Certificate of Analysis supplied with the given batch is strongly recommended.

The reagent is not intended for diagnostic, therapeutic or consumer use. Responsibility for the lawful and safe use of the substance rests with the purchaser acting as a research entity.

BRM-SLU-18MG

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