Disponibilità: 249999998 in magazzino
Sildenafil ≥99% — chemical reagent for laboratory, research and analytical use. Not for human or animal consumption.
Tadalafil ≥99% — pure substance
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Tadalafil (research reagent)
WARNING: Chemical reagent intended solely for laboratory, research and analytical purposes. NOT FOR HUMAN OR ANIMAL CONSUMPTION. It is not a medicinal product, dietary supplement or food.
Tadalafil is an organic heterocyclic compound belonging to the β-carboline derivative class, used in laboratories as an analytical standard and reference reagent in studies of selective phosphodiesterase type 5 (PDE5) inhibitors. In a research context it is one of the model ligands of this enzyme, which makes it widely used in experimental pharmacology, analytical chemistry and studies of cyclic-GMP-based cellular signalling mechanisms.
Physicochemical data
| IUPAC name | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione |
| Synonyms | Tadalafil, IC-351 |
| CAS number | 171596-29-5 |
| Molecular formula | C22H19N3O4 |
| Molar mass | 389.40 g/mol |
| Appearance | White to slightly off-white crystalline powder |
| Solubility | Soluble in DMSO; very poorly soluble in water (< 1 mg/mL) and in ethanol |
| Melting point | literature values vary (approx. 276–302 °C depending on source and crystalline form) |
| Purity | ≥99% |
Characteristics and research applications
The tadalafil molecule is built on a fused, polycyclic pyrazinopyridoindole scaffold bearing a 1,3-benzodioxole group. The presence of two stereogenic centres (6R,12aR configuration) means the compound occurs as a single, well-defined diastereomer, making it a convenient standard for chiral assays and optical-purity studies. Its rigid, planar-cyclic architecture and the dione moieties give rise to characteristic UV and MS spectra used for analytical identification.
In a research context tadalafil is described as a selective inhibitor of phosphodiesterase type 5 — the enzyme responsible for hydrolysis of cyclic guanosine monophosphate (cGMP). In in-vitro model systems it serves as a tool for studying PDE5 inhibition kinetics, selectivity against other phosphodiesterase isoforms and for calibrating enzymatic assays. Because of its low aqueous solubility, working solutions are usually prepared as DMSO stock solutions that are subsequently diluted in experimental buffers.
As an analytical reagent tadalafil is used as a reference substance in HPLC and LC-MS methods for the validation of assay and identity-control procedures. Its high purity (≥99%) makes it suitable for preparing calibration curves and as a reference material in method-development studies. The product should be stored in a dry, cool place, away from light and moisture. The material is intended solely for laboratory applications carried out by qualified personnel using appropriate personal protective equipment.
Tadalafil ≥99% — chemical reagent for laboratory, research and analytical use. Not for human or animal consumption.
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