FLModafinil ≥99% — pure substance

FLModafinil (Lauflumid, CRL-40,940)

FLModafinil (also known as lauflumid or CRL-40,940) is a bis-fluorinated structural analogue of modafinil. In the molecule both phenyl rings of the benzhydryl fragment are substituted with a fluorine atom at the para position, which distinguishes it from the parent modafinil. The compound belongs to the group of eugeroic research compounds and is offered here as a high-purity reagent for laboratory use and as a reference standard for analytical chemistry.

Physicochemical data

Characterisation and research applications

FLModafinil differs from modafinil by the presence of two fluorine atoms at the para positions of both aromatic rings. The introduction of fluorine — an element of high electronegativity and small atomic radius — is a common strategy in medicinal chemistry, used to modify the electronic properties, lipophilicity and metabolic stability of a molecule without significantly altering its geometry. For this reason fluorinated analogues such as FLModafinil are valuable tools in structure–activity relationship (SAR) studies within the eugeroic class of compounds. Like modafinil, the molecule possesses a chiral centre at the sulfur atom of the sulfinyl group.

In the scientific literature FLModafinil is described as an experimental modafinil analogue studied for its wakefulness-promoting properties. Because of its structural kinship with modafinil, it serves as a reference point in comparative studies of the mechanism of action of eugeroics, including their interaction with the dopamine transporter (DAT) and the neurotransmitter systems that regulate sleep and wakefulness. It should be emphasised that the available data on this compound come mainly from preclinical research and its profile remains a subject of further study — which is why it is a typical tool compound of investigative value.

As a laboratory reagent, FLModafinil is used primarily as a reference substance in chromatographic methods (HPLC, LC-MS/MS, GC-MS) — for calibration, validation of analytical methods, quantification and identification, including in toxicology and quality control. The high purity of ≥99% is essential for the reproducibility and reliability of analytical results. The material should be stored in a tightly sealed container, in a dry and cool place, away from light and moisture, in accordance with good laboratory practice. All work should be carried out using appropriate personal protective equipment. The product is intended exclusively for qualified research personnel and has no consumer application.