Bromantan – Pure Crystal ≥99%

Bromantane (Ladasten)

Bromantane is a synthetic adamantane derivative in which the caged adamantane skeleton is linked through an amine bridge to a 4-bromophenyl ring. The compound was developed in the 1980s at research institutes in the former USSR and is described in the scientific literature as a representative of the so-called actoprotectors — a class of substances studied for their influence on an organism's performance under conditions of physical strain. It is offered here as a high-purity research reagent and as a reference standard for analytical chemistry.

Physicochemical data

Characterisation and research applications

Structurally, bromantane combines two characteristic motifs: a rigid, lipophilic adamantane core and a halogenated aromatic ring. The adamantane core — a highly symmetric three-dimensional cage structure — confers substantial lipophilicity and metabolic stability, which is why adamantane and its derivatives are a popular scaffold in medicinal chemistry and in the design of tool compounds. The bromine atom at the para position of the phenyl ring makes the compound a convenient starting point for cross-coupling reactions and for structure–activity relationship studies.

In the scientific literature bromantane is discussed in the context of research on the dopaminergic system: experimental work suggests an effect on the expression of enzymes involved in catecholamine biosynthesis, making it an interesting tool in neuropharmacological in vitro and animal research models. Owing to its classification as an actoprotector, it is also studied in the context of mechanisms of adaptation to stress and physical load. It is worth noting that bromantane appears on the World Anti-Doping Agency (WADA) prohibited list, which additionally makes it an important analyte in sports toxicology and forensic chemistry.

As a laboratory reagent, bromantane is used primarily as a reference substance in chromatographic methods (HPLC, GC-MS, LC-MS) — for calibration, validation of analytical methods and identification in samples of unknown composition. The declared high purity of ≥99% is essential for reproducibility and accurate quantification. The material should be stored in a tightly sealed container, in a dry place, away from light and moisture, in accordance with good laboratory practice. All work should be carried out with appropriate personal protective equipment. The product is intended exclusively for qualified research personnel and has no consumer application.