Modafinil ≥99% — crystal clear, no fillers

Modafinil

Modafinil is a synthetic benzhydrylsulfinylacetamide derivative belonging to the group of eugeroic (wakefulness-promoting) compounds intensively studied in neuropharmacology. The molecule contains a characteristic sulfinyl group (S=O) linking a diphenylmethyl fragment to an acetamide residue, which gives it chiral properties. It is offered here as a high-purity research reagent and as a reference standard for analytical and toxicological chemistry.

Physicochemical data

Characterisation and research applications

Modafinil is a chiral molecule — it exists as two enantiomers (R and S) differing in the configuration around the sulfur atom of the sulfinyl group. The racemate (a 1:1 mixture) and the pure R enantiomer (armodafinil) are subjects of separate studies, because the enantiomers differ in their pharmacokinetic profiles. The sulfinyl group makes the molecule an interesting object of study in organosulfur chemistry, including the oxidation of sulfides to sulfoxides and sulfones.

In the scientific literature modafinil is classified as a wakefulness-promoting agent with a mechanism distinct from that of classical amphetamine stimulants. Experimental work indicates its interaction with the dopamine transporter (DAT) as a weak, atypical dopamine reuptake inhibitor, as well as effects on the orexinergic, histaminergic and noradrenergic systems in research models. As a result, modafinil is widely used as a tool compound in neurobiological research on the regulation of sleep and wakefulness and on catecholamine neurotransmission in vitro and in animal models.

As a laboratory reagent, modafinil serves primarily as a reference substance in chromatographic methods (HPLC, LC-MS/MS, GC-MS) — for calibration, method validation, quantification and identification in biological samples and in anti-doping control, where the substance appears on the WADA list. The high purity of ≥99% is essential for the reliability of analytical determinations. The material should be stored in a tightly sealed container, in a dry and cool place, protected from light and moisture, in accordance with good laboratory practice. Work should be carried out using appropriate personal protective equipment. The product is intended exclusively for qualified research personnel and has no consumer application.