Sunifiram ≥99% — pure substance

Sunifiram (DM-235)

Sunifiram, also designated by the laboratory code DM-235, is a synthetic organic compound based on a piperazine core, studied in the biomedical sciences as a substance with ampakine properties. The molecule combines a piperazine ring with a benzoyl group and a propanoyl moiety, forming a structure of well-defined geometry. Sunifiram was developed during work on piracetam-like compounds, yet structurally it represents a class distinct from the classical racetams. Owing to its marked activity in experimental models, it is a frequent subject of neuropharmacological research.

Physicochemical data

Characteristics and research applications

Sunifiram is a molecule symmetrical about its central piperazine ring, whose two nitrogen atoms are substituted with a benzoyl and a propanoyl group respectively. This structure gives the compound two amide groups of differing reactivity, making it an interesting model in studies of amide chemistry and hydrolytic stability. Unlike many related compounds, Sunifiram contains no stereocentre, so its analytical characterisation is unambiguous.

In analytical laboratories the compound is used as a reference standard in liquid chromatography (HPLC, UPLC) with UV detection and in mass spectrometry. Its well-defined molecular mass and characteristic spectra (NMR, IR, MS) facilitate identification, quantification and the validation of analytical methods and quality-control procedures. The aromatic ring of the benzoyl group provides strong UV absorption, which is useful in chromatographic assays.

In experimental neurobiology, Sunifiram is described as a compound with ampakine activity, studied in the context of glutamatergic transmission modulation and synaptic plasticity mechanisms in in vitro and animal models. It is used as a tool in studies of AMPA and NMDA receptors and in structure–activity relationship analyses within piperazine compounds. All of these applications are strictly research in nature; this description contains no health recommendations or dosage information.

The material should be stored in a tightly closed container in a cool, dry place, protected from light. Personal protective equipment should be used at all times in accordance with good laboratory practice.